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Six IARC Regional Hubs for Cancer Registration have been established to cover Africa, Asia, the Caribbean, Latin America, and Oceania. Each Hub acts as the main point of contact for countries within its catchment area as the overall regional coordinating body for GICR activities. A designated Principal Investigator has local responsibility for the operations of each Hub. Regional Hub Advisory Committees provide strategic advice to guide decisions.

To better serve the needs across each region, IARC GICR Collaborating Centres are being established. The objective is to identify established cancer organizations as partners to strengthen capacity in cancer registration. Each Collaborating Centre contributes to one or more Hubs through specific functions, subject interests and, in some cases, identified geographical areas.